URL: http://www.clinicaltrials.gov. Of the 2371 participants randomized to standard therapy, 2215 (93.4%) were included. Follow-up was available for 4446 patients, 2231 were randomized to intensive and 2215 to standard therapy. HR is adjusted for age and sex. Finally, the ACCORD-BP study only included patients with type 2 diabetes mellitus and although the association between an increase in serum creatinine and increased risk of adverse clinical outcomes is also observed in other populations, effects of intensive BP-lowering treatment may be different. Use salvia. Effects of intensive blood-pressure control in type 2 diabetes mellitus. Acute change in glomerular filtration rate with inhibition of the renin-angiotensin system does not predict subsequent renal and cardiovascular outcomes. Of the 2362 participants randomized to intensive therapy, 2231 (94.5%) were included in the present analysis. The controlled blood pressure can help protect the residual kidney function and reduce creatinine and blood urea levels. All rights reserved. Blood tests can be used to look for the causes of high blood pressure, and to look for damage to organs caused by untreated hypertension. In the intensive treatment group, visits were scheduled once a month for the first 4 months and every 2 months thereafter. 7272 Greenville Ave. Antibiotics such as Amphotercin B, Gentamycin and Vancomycin can also cause damage to the kidneys and raise creatinine levels. This supports the hypothesis that a decline in renal function as a result of antihypertensive therapy should not be interpreted as harmful. Diuretics like furosemide (Lasix) are also believed to be able to cause elevation of creatinine level as they can cause the kidney’s to work overtime trying to compensate. Sometimes, low levels of the substance may indicate less serious issues like pregnancy or reduced muscle mass among elderly persons. For inclusion in the BP trial, participants were required to have an SBP between 130 and 180 mm Hg with 3 or fewer antihypertensive medications, and a 24-hour protein excretion rate of <1.0 g. This trial was sponsored by the National Heart, Lung and Blood Institute, and the protocol was approved by the institutional review board of each participating center and by an independent review committee of the National Heart, Lung and Blood Institute. Our data are in apparent contrast with an earlier analysis of the SPRINT (Systolic Blood Pressure Intervention Trial) and ACCORD trials that reported an increased risk of CKD in patients receiving intensive BP-lowering treatment with and without diabetes mellitus.23 However, both in the original and our post hoc analysis of the ACCORD trial, no evidence for an increased risk for renal failure was found in the intensive group compared with the standard group. High blood pressure is a leading cause for Chronic Kidney Disease (CKD).If you have high blood pressure about five to ten years,you are possible to suffer from high creatinine level. In this situation, the loss of renal function after initiation of therapy reflects the hemodynamic effect of a lower perfusion pressure on glomerular filtration rate, but not a loss of functional nephrons.6 An important concern, however, is that the increase in creatinine is caused by ischemic nephropathy as a result of inadequate renal perfusion. All clinical end points were adjudicated by a committee blinded to the treatment assignment. © American Heart Association, Inc. All rights reserved. The National Heart, Lung, and Blood Institute sponsored the ACCORD trial (Action to Control Cardiovascular Risk in Diabetes). 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